Journal
NATURE BIOMEDICAL ENGINEERING
Volume 4, Issue 4, Pages 381-393Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41551-020-0525-x
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Funding
- National Institutes of Health (NIH) through National Center for Advancing Translational Sciences (NCATS)
- National Institutes of Health (NIH) through National Institute of Environmental Health Sciences (NIEHS)
- National Institutes of Health (NIH) through Eunice Kennedy Shriver National Institute of Child Health and Development (NICHD)
- National Institutes of Health (NIH) through Office of Women's Health Research (ORWH)
- National Institute for Environmental Health Sciences/National Center for Advancing Translational Sciences [UH3TR001207, 4UH3ES029073-03]
- Bill & Melinda Gates Foundation [OPP1161206]
- Thomas J. Watkin's Memorial Professorship
- National Institute of Aging [F30AG058387]
- National Institute for Child Health and Development [F31HD089693]
- National Institutes of Health (NIH) through NIH Common Fund
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Engineered male and female biomimetic reproductive tissues are being developed as autonomous in vitro units or as integrated multi-organ in vitro systems to support germ cell and embryo function, and to display characteristic endocrine phenotypic patterns, such as the 28-day human ovulatory cycle. In this Review, we summarize how engineered reproductive tissues facilitate research in reproductive biology, and overview strategies for making engineered reproductive tissues that might eventually allow the restoration of reproductive capacity in patients. This Review summarizes progress in the development of engineering strategies employed in reproductive science and medicine, with a focus on biomaterials and microfluidic approaches.
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