Journal
BLOOD
Volume 125, Issue 9, Pages 1383-1386Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2014-08-569228
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Funding
- Leukaemia and Lymphoma Research
- Wellcome Trust
- European Research Council
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Intrachromosomal amplification of chromosome 21 (iAMP21) defines a distinct cytogenetic subgroup of childhood B-cell precursor acute lymphoblastic leukemia. Breakage-fusion-bridge cycles followed by chromothripsis and other complex structural rearrangements of chromosome 21 underlie the mechanism giving rise to iAMP21. Patients with iAMP21 are older (median age 9 years), with a low white cell count. They have a high relapse rate when treated as standard risk. Recent studies have shown improved outcome on intensive therapy. Molecular targets for therapy are being sought.
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