Application of Solidago chilensis and laser improved the repair of burns in diabetic rats

Background: The repair of burns in diabetic patients is a clinical problem. It is relevant to study alternative therapies that can improve the healing process. Our aim was to inves-tigate the effects of Solidago chilensis associated or not with laser on burns in diabetic rats. Methods: The animals were divided in four groups (n 1/4 30): C-without treatment; S-S. chilensis extract; L-laser irradiated; LS-laser and S. chilensis. In 7, 14 and 21 days samples were collected after the injury to structural, morphometric and molecular analysis. Results: Our results demonstrate the association of S. chilensis and laser reduced the in-flammatory infiltrate and favored the angiogenesis. In the groups treated only with laser or with the plant extract showed higher levels of VEGF. The low-level laser therapy (LLLT) promoted higher collagen I and reduction of collagen III. It was also observed higher MMP-2 activation and a decreasing of the active isoform of MMP-9 in the S, L and LS groups. Conclusions: The treatments improved the repair of burns in diabetic rats, since it reduced the inflammatory infiltrate and favored the collagen organization presenting similar effects in the burn repair of the diabetics.

Automated summary

The combination therapy of Solidago chilensis and laser reduced inflammatory infiltrate and promoted angiogenesis in burns of diabetic rats. Laser or plant extract alone showed higher levels of VEGF. Low-level laser therapy increased collagen I and decreased collagen III, as well as activated MMP-2 and reduced active MMP-9 isoform.