Channel and Spatial Attention Regression Network for Cup-to-Disc Ratio Estimation

Cup-to-disc ratio (CDR) is of great importance during assessing structural changes at the optic nerve head (ONH) and diagnosis of glaucoma. While most efforts have been put on acquiring the CDR number through CNN-based segmentation algorithms followed by the calculation of CDR, these methods usually only focus on the features in the convolution kernel, which is, after all, the operation of the local region, ignoring the contribution of rich global features (such as distant pixels) to the current features. In this paper, a new end-to-end channel and spatial attention regression deep learning network is proposed to deduces CDR number from the regression perspective and combine the self-attention mechanism with the regression network. Our network consists of four modules: the feature extraction module to extract deep features expressing the complicated pattern of optic disc (OD) and optic cup (OC), the attention module including the channel attention block (CAB) and the spatial attention block (SAB) to improve feature representation by aggregating long-range contextual information, the regression module to deduce CDR number directly, and the segmentation-auxiliary module to focus the model's attention on the relevant features instead of the background region. Especially, the CAB selects relatively important feature maps in channel dimension, shifting the emphasis on the OD and OC region; meanwhile, the SAB learns the discriminative ability of feature representation at pixel level by capturing the relationship of intra-feature map. The experimental results of ORIGA dataset show that our method obtains absolute CDR error of 0.067 and the Pearson's correlation coefficient of 0.694 in estimating CDR and our method has a great potential in predicting the CDR number.