Journal
OPEN FORUM INFECTIOUS DISEASES
Volume 7, Issue 5, Pages -Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/ofid/ofaa158
Keywords
Candida auris; drug resistance; whole-genome sequencing
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Whole-genome sequencing clustered Australian Candida auris isolates from sporadic cases within clade III. Case isolates were genomically distinct; however, unexpectedly, those from 1 case comprised 2 groups separated by >60 single nucleotide polymorphisms (SNPs) with no isolate being identical, in contrast to outbreaks where isolates from any 1 individual have differed by <3 SNPs. Multidrug resistance was absent. High within-host genetic heterogeneity should be considered when investigating C. auris infections.
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