Journal
PHARMACEUTICS
Volume 12, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/pharmaceutics12030276
Keywords
drug delivery; erythrocyte; carrier erythrocyte; erythrocyte-bioreactor; targeted drug delivery; therapy; diagnostics
Categories
Funding
- Ministry of Science and Higher Education of the Russian Federation [AAAA-A17-117112420087-0, AAAA-A19-119111690006-9]
- Russian Foundation for Basic Research [N 19-34-90035, N 19-34-90036]
- Presidium of the Russian Academy of Sciences, the Program for fundamental research Fundamentals of the technology of physiological adaptations
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Drug delivery using natural biological carriers, especially erythrocytes, is a rapidly developing field. Such erythrocytes can act as carriers that prolong the drug's action due to its gradual release from the carrier; as bioreactors with encapsulated enzymes performing the necessary reactions, while remaining inaccessible to the immune system and plasma proteases; or as a tool for targeted drug delivery to target organs, primarily to cells of the reticuloendothelial system, liver and spleen. To date, erythrocytes have been studied as carriers for a wide range of drugs, such as enzymes, antibiotics, anti-inflammatory, antiviral drugs, etc., and for diagnostic purposes (e.g., magnetic resonance imaging). The review focuses only on drugs loaded inside erythrocytes, defines the main lines of research for erythrocytes with bioactive substances, as well as the advantages and limitations of their application. Particular attention is paid to in vivo studies, opening-up the potential for the clinical use of drugs encapsulated into erythrocytes.
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