Journal
WORLD JOURNAL OF STEM CELLS
Volume 12, Issue 5, Pages 323-338Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.4252/wjsc.v12.i5.323
Keywords
Neurodegenerative diseases; Stem cells; Brain-derived neurotrophic factor; Glial cell line-derived neurotrophic factor; Nerve growth factor; Combination therapy
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Funding
- Social Development Project of Jiangsu Science and Technology Department [BE2015721]
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Neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis, are a group of incurable neurological disorders, characterized by the chronic progressive loss of different neuronal subtypes. However, despite its increasing prevalence among the ever-increasing aging population, little progress has been made in the coincident immense efforts towards development of therapeutic agents. Research interest has recently turned towards stem cells including stem cells-derived exosomes, neurotrophic factors, and their combination as potential therapeutic agents in neurodegenerative diseases. In this review, we summarize the progress in therapeutic strategies based on stem cells combined with neurotrophic factors and mesenchymal stem cells-derived exosomes for neurodegenerative diseases, with an emphasis on the combination therapy.
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