Journal
WORLD JOURNAL OF STEM CELLS
Volume 12, Issue 4, Pages 266-276Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.4252/wjsc.v12.i4.266
Keywords
Low back pain; Intervertebral disc degeneration; Stem cell niche; Stem; progenitor cell; Endogenous repair strategy; Stem cell treatment
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Funding
- National Natural Science Foundation of China [81972136]
- National Natural Science Foundation for Young Scholars of China [81401830]
- Guangxi Natural Science Foundation General Project [2018JJA14775]
- Young Medical Scholars Major Program of Jiangsu Province [QNRC2016342]
- Innovation Team Project of Jiangsu Province [CXTDB2017004]
- Key Funding Project of Maternal and Child Health Research of Jiangsu Province [F201801]
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Low back pain has become more prevalent in recent years, causing enormous economic burden for society and government. Common therapies used in clinics including conservative treatment and surgery can only relieve pain. Subsequent cell-based treatment such as mesenchymal stem cell transplantation poses problems such as short duration of therapeutic effect and tumorigenesis. Recently, the discovery and identification of stem cell niche and stem/progenitor cells in intervertebral disc bring increased attention to endogenous repair strategy. Therefore, we review the studies involving endogenous repair strategy and present the characteristics and current status of this treatment. Meanwhile, we also discuss the strategy and perspective of endogenous repair strategy in future.
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