Journal
FRONTIERS IN ONCOLOGY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2020.00389
Keywords
lncRNAs; SNHG; snoRNA; cancer; malignant disease; proliferation; invasion
Categories
Funding
- Competitivity Operational Program, 2014-2020, entitled Clinical and economical impact of personalized targeted anti-microRNA therapies in reconverting lung cancer chemoresistance-CANTEMIR [35/01.09.2016, MySMIS 103375]
- project PNCDI III 2015-2020 entitled Increasing the performance of scientific research and technology transfer in translational medicine through the formation of a new generation of young researchers-ECHITAS [29PFE/18.10.2018]
- [PNIII-P1-1.2-PCCDI2017-0737]
- [35/2018]
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The small nucleolar RNA host genes (SNHGs) are a group of long non-coding RNAs, which are reported in many studies as being overexpressed in various cancers. With very few exceptions, the SNHGs (SNHG1, SNHG3, SNHG5, SNHG6, SNHG7, SNHG12, SNHG15, SNHG16, SNHG20) are recognized as inducing increased proliferation, cell cycle progression, invasion, and metastasis of cancer cells, which makes this class of transcripts a viable biomarker for cancer development and aggressiveness. Through our literature research, we also found that silencing of SNHGs through small interfering RNAs or short hairpin RNAs is very effective in both in vitro and in vivo experiments by lowering the aggressiveness of solid cancers. The knockdown of SNHG as a new cancer therapeutic option should be investigated more in the future.
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