Related references
Note: Only part of the references are listed.Peptide-mediated drug delivery across the blood-brain barrier for targeting brain tumors
Behzad Jafari et al.
EXPERT OPINION ON DRUG DELIVERY (2019)
Understanding PDE4's function in Alzheimer's disease; a target for novel therapeutic approaches
Amy J. Tibbo et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2019)
Crossing the blood-brain-barrier with nanoligand drug carriers self-assembled from a phage display peptide
Lin-Ping Wu et al.
NATURE COMMUNICATIONS (2019)
Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory Diseases
Heng Li et al.
FRONTIERS IN PHARMACOLOGY (2018)
Phosphodiesterase 4b expression plays a major role in alcohol-induced neuro-inflammation
Diana V. Avila et al.
NEUROPHARMACOLOGY (2017)
Therapeutic benefits of phosphodiesterase 4B inhibition after traumatic brain injury
Nicole M. Wilson et al.
PLOS ONE (2017)
Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition
Alexander McGirr et al.
NEUROPSYCHOPHARMACOLOGY (2016)
Blood-brain barrier shuttle peptides: an emerging paradigm for brain delivery
Benjami Oller-Salvia et al.
CHEMICAL SOCIETY REVIEWS (2016)
Association of PDE4B Polymorphisms with Susceptibility to Schizophrenia: A Meta-Analysis of Case-Control Studies
Yanguo Feng et al.
PLOS ONE (2016)
The cAMP Pathway as Therapeutic Target in Autoimmune and Inflammatory Diseases
Verena Katharina Raker et al.
FRONTIERS IN IMMUNOLOGY (2016)
Ten-Year Employment Patterns of Working Age Individuals After Moderate to Severe Traumatic Brain Injury: A National Institute on Disability and Rehabilitation Research Traumatic Brain Injury Model Systems Study
Jeffrey P. Cuthbert et al.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION (2015)
Engineered stabilization and structural analysis of the autoinhibited conformation of PDE4
Peder Cedervall et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
The Interplay between Cyclic AMP, MAPK, and NF-κB Pathways in Response to Proinflammatory Signals in Microglia
Mousumi Ghosh et al.
BIOMED RESEARCH INTERNATIONAL (2015)
The upstream conserved regions (UCRs) mediate homo- and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s)
Moses Xie et al.
BIOCHEMICAL JOURNAL (2014)
Select 3′,5′-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain
Michy P. Kelly et al.
CELLULAR SIGNALLING (2014)
Structural basis for the design of selective phosphodiesterase 4B inhibitors
David Fox et al.
CELLULAR SIGNALLING (2014)
Inhibition of phosphodiesterase 4 reduces ethanol intake and preference in C57BL/6J mice
Yuri A. Blednov et al.
FRONTIERS IN NEUROSCIENCE (2014)
Identification of the fused bicyclic 4-amino-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors
Taiji Goto et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)
Combining Neurotrophin-Transduced Schwann Cells and Rolipram to Promote Functional Recovery From Subacute Spinal Cord Injury
Govinder Flora et al.
CELL TRANSPLANTATION (2013)
PDE4 as a target for cognition enhancement
Wito Richter et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2013)
Heavy Ethanol Intoxication Increases Proinflammatory Cytokines and Aggravates Hemorrhagic Shock-Induced Organ Damage in Rats
Tsung-Ming Hu et al.
MEDIATORS OF INFLAMMATION (2013)
AGE-DEPENDENT ALTERATIONS IN CAMP SIGNALING CONTRIBUTE TO SYNAPTIC PLASTICITY DEFICITS FOLLOWING TRAUMATIC BRAIN INJURY
D. J. Titus et al.
NEUROSCIENCE (2013)
Effects of early rolipram treatment on histopathological outcome after controlled cortical impact injury in mice
Coleen M. Atkins et al.
NEUROSCIENCE LETTERS (2013)
PDE Inhibition and cognition enhancement
Arjan Blokland et al.
EXPERT OPINION ON THERAPEUTIC PATENTS (2012)
Proinflammatory cytokine regulation of cyclic AMP-phosphodiesterase 4 signaling in microglia in vitro and following CNS injury
Mousumi Ghosh et al.
GLIA (2012)
A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins
Jennifer E. Eykelenboom et al.
HUMAN MOLECULAR GENETICS (2012)
Phosphodiesterase isoform-specific expression induced by traumatic brain injury
Anthony A. Oliva et al.
JOURNAL OF NEUROCHEMISTRY (2012)
Cognitive decline in older adults with a history of traumatic brain injury
Laura Moretti et al.
LANCET NEUROLOGY (2012)
Comparison of cAMP-specific phosphodiesterase mRNAs distribution in mouse and rat brain
Emily M. Johansson et al.
NEUROSCIENCE LETTERS (2012)
cAMP: Novel concepts in compartmentalised signalling
Helen V. Edwards et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2012)
CREB: a multifaceted regulator of neuronal plasticity and protection
Kensuke Sakamoto et al.
JOURNAL OF NEUROCHEMISTRY (2011)
PKA Phosphorylation of NDE1 Is DISC1/PDE4 Dependent and Modulates Its Interaction with LIS1 and NDEL1
Nicholas J. Bradshaw et al.
JOURNAL OF NEUROSCIENCE (2011)
Enhanced long-term depression and impaired reversal learning in phosphodiesterase 4B-knockout (PDE4B-/-) mice
Kris Rutten et al.
NEUROPHARMACOLOGY (2011)
Mammalian Cyclic Nucleotide Phosphodiesterases: Molecular Mechanisms and Physiological Functions
Sharron H. Francis et al.
PHYSIOLOGICAL REVIEWS (2011)
Inhibition of phosphodiesterase-4 decreases ethanol intake in mice
Wei Hu et al.
PSYCHOPHARMACOLOGY (2011)
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
Taro Kawai et al.
NATURE IMMUNOLOGY (2010)
The Role of Type 4 Phosphodiesterases in Generating Microdomains of cAMP: Large Scale Stochastic Simulations
Rodrigo F. Oliveira et al.
PLOS ONE (2010)
cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action
Sharron H. Francis et al.
PHARMACOLOGICAL REVIEWS (2010)
CYCLIC AMP-SPECIFIC PDEs: A PROMISING THERAPEUTIC TARGET FOR CNS REPAIR
Mousumi Ghosh et al.
TRANSLATIONAL NEUROSCIENCE (2010)
Seizures, Enhanced Excitation, and Increased Vesicle Number in Lis1 Mutant Mice
Joel S. F. Greenwood et al.
ANNALS OF NEUROLOGY (2009)
Discovery of selective PDE4B inhibitors
Kenji Naganuma et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases
George S. Baillie
FEBS JOURNAL (2009)
Critical Role of TLR4 Response in the Activation of Microglia Induced by Ethanol
Sara Fernandez-Lizarbe et al.
JOURNAL OF IMMUNOLOGY (2009)
An essential role of the aPKC-Aurora A-NDEL1 pathway in neurite elongation by modulation of microtubule dynamics
Daisuke Mori et al.
NATURE CELL BIOLOGY (2009)
NCS-1 in the Dentate Gyrus Promotes Exploration, Synaptic Plasticity, and Rapid Acquisition of Spatial Memory
Bechara J. Saab et al.
NEURON (2009)
Phosphodiesterase 4B2 gene is an effector of Toll-like receptor signaling in astrocytes
Elizabeth Borysiewicz et al.
METABOLIC BRAIN DISEASE (2009)
Transcription Factors in Long-Term Memory and Synaptic Plasticity
Cristina M. Alberini
PHYSIOLOGICAL REVIEWS (2009)
Regulation of amygdalar PKA by β-arrestin-2/phosphodiesterase-4 complex is critical for fear conditioning
Yuting Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Enhanced PDE4B expression augments LPS-inducible TNF expression in ethanol-primed monocytes: relevance to alcoholic liver disease
Leila Gobejishvili et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2008)
DISC1, PDE4B, and NDE1 at the centrosome and synapse
Nicholas J. Bradshaw et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cells
Yidong Shen et al.
DEVELOPMENTAL CELL (2008)
Increased MCP-1 and microglia in various regions of the human alcoholic brain
Jun He et al.
EXPERIMENTAL NEUROLOGY (2008)
Lis1 and Ndel1 influence the timing of nuclear envelope breakdown in neural stem cells
Sachin Hebbar et al.
JOURNAL OF CELL BIOLOGY (2008)
Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment
Liya Qin et al.
JOURNAL OF NEUROINFLAMMATION (2008)
Up-regulation of exploratory tendencies does not enhance general learning abilities in juvenile or young-adult outbred mice
Kenneth R. Light et al.
NEUROBIOLOGY OF LEARNING AND MEMORY (2008)
Behavioral characterization of mice deficient in the phosphodiesterase-10A (PDE10A) enzyme on a C57/B16N congenic background
Judith A. Siuciak et al.
NEUROPHARMACOLOGY (2008)
PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia
S. Hossein Fatemi et al.
SCHIZOPHRENIA RESEARCH (2008)
Anxiogenic-like behavioral phenotype of mice deficient in phosphodiesterase 4B (PDE4B)
Han-Ting Zhang et al.
NEUROPSYCHOPHARMACOLOGY (2008)
Live-cell imaging of cAMP dynamics
Debbie Willoughby et al.
NATURE METHODS (2008)
Differential distribution of PDE4B splice variant mRNAs in rat brain and the effects of systemic administration of LPS in their expression
Elisabet Reyes-Irisarri et al.
SYNAPSE (2008)
Modulation of the cAMP signaling pathway after traumatic brain injury
Coleen M. Atkins et al.
EXPERIMENTAL NEUROLOGY (2007)
Lissencephaly and LIS1: insights into the molecular mechanisms of neuronal migration and development
A. Wynshaw-Boris
CLINICAL GENETICS (2007)
Selective induction of cAMP phosphodiesterase PDE4132 expression in experimental autoimmune encephalomyelitis
Ellsabet Reyes-Irisarri et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2007)
Disrupted-in-schizophrenia 1 regulates integration of newly generated neurons in the adult brain
Xin Duan et al.
CELL (2007)
Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels
Hannah Murdoch et al.
JOURNAL OF NEUROSCIENCE (2007)
PDE4B5, a novel, super-short, brain-specific cAMP phosphodiesterase-4 variant whose isoform-specifying N-terminal region is identical to that of cAMP phosphodiesterase-4D6 (PDE4D6)
York-Fong Cheung et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)
Antipsychotic profile of rolipram: efficacy in rats and reduced sensitivity in mice deficient in the phosphodiesterase-4B (PDE4B) enzyme
Judith A. Siuciak et al.
PSYCHOPHARMACOLOGY (2007)
The centrosome in neuronal development
Holden R. Higginbotham et al.
TRENDS IN NEUROSCIENCES (2007)
cAMP signaling in leukocyte transendothelial migration
Magdalena J. Lorenowicz et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2007)
cAMP-specific phosphodiesterase-4 enzymes in the cardiovascular system - A molecular toolbox for generating compartmentalized cAMP signaling
Miles D. Houslay et al.
CIRCULATION RESEARCH (2007)
Disrupted in schizophrenia 1 interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia
L. M. Camargo et al.
MOLECULAR PSYCHIATRY (2007)
PGE1 stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]:: role of compartmentalized phosphodiesterases
Anna Terrin et al.
JOURNAL OF CELL BIOLOGY (2006)
Chronic ethanol-mediated decrease in cAMP primes macrophages to enhanced LPS-inducible NF-KB activity and TNF expression:: relevance to alcoholic liver disease
Leila Gobejishvili et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2006)
Restricted diffusion of a freely diffusible second messenger: mechanisms underlying compartmentalized cAMP signalling
M. Zaccolo et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2006)
Disability in young people and adults after head injury: 5-7 year follow up of a prospective cohort study
L Whitnall et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2006)
Monitoring of cAMP synthesis and degradation in living cells
VO Nikolaev et al.
PHYSIOLOGY (2006)
Toll-like receptors in central nervous system glial inflammation and homeostasis
T Kielian
JOURNAL OF NEUROSCIENCE RESEARCH (2006)
Improving memory: A role for phosphodiesterases
A. Blokland et al.
CURRENT PHARMACEUTICAL DESIGN (2006)
Cyclic nucleotide phosphodiesterases: Molecular regulation to clinical use
Andrew T. Bender et al.
PHARMACOLOGICAL REVIEWS (2006)
Exploration in outbred mice covaries with general learning abilities irrespective of stress reactivity, emotionality, and physical attributes
Louis D. Matzel et al.
NEUROBIOLOGY OF LEARNING AND MEMORY (2006)
DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling
JK Millar et al.
SCIENCE (2005)
Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration
K Toyo-Oka et al.
HUMAN MOLECULAR GENETICS (2005)
Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages
SLC Jin et al.
JOURNAL OF IMMUNOLOGY (2005)
Induction of arginase I transcription by IL-4 requires a composite DNA response element for STAT6 and C/EBPβ
MJ Gray et al.
GENE (2005)
Phosphodiesterase 4B (PDE4B) and cAMP-level regulation within different tissue fractions of rat hippocarnpal slices during long-terin potentiation in vitro
T Ahmed et al.
BRAIN RESEARCH (2005)
LPS activation of Toll-like receptor 4 signals CD11b/CD18 expression in neutrophils
XM Zhou et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2005)
Transgenic mice expressing a truncated form of CREB-binding protein (CBP) exhibit deficits in hippocampal synaptic plasticity and memory storage
MA Wood et al.
LEARNING & MEMORY (2005)
CREB-mediated Bcl-2 protein expression after ischemic preconditioning
R Meller et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2005)
Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence
PJ Harrison et al.
MOLECULAR PSYCHIATRY (2005)
Antidepressant effects of inhibitors of cAMP phosphodiesterase (PDE4)
JM O'Donnell et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2004)
Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation
M Ariga et al.
JOURNAL OF IMMUNOLOGY (2004)
The oligomerization state determines regulatory properties and inhibitor sensitivity of type 4 cAMP-specific phosphodiesterases
W Richter et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Pleiotropic function of Toll-like receptors
T Kaisho et al.
MICROBES AND INFECTION (2004)
Regulation of the phosphodiesterase PDE4B3-isotype during long-term potentiation in the area dentata in vivo
T Ahmed et al.
NEUROSCIENCE (2004)
Remodelling of the PDE4 cAMP phosphodiesterase isoform profile upon monocyte-macrophage differentiation of human U937 cells
MC Shepherd et al.
BRITISH JOURNAL OF PHARMACOLOGY (2004)
Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders
NJ Brandon et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2004)
Recognition of microbial infection by Toll-like receptors
E Kopp et al.
CURRENT OPINION IN IMMUNOLOGY (2003)
Molecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoform
M Shepherd et al.
BIOCHEMICAL JOURNAL (2003)
PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization
MD Houslay et al.
BIOCHEMICAL JOURNAL (2003)
Expression of the specific type IV phosphodiesterase gene PDE4B3 during different phases of long-term potentiation in single hippocampal slices of rats in vitro
T Ahmed et al.
NEUROSCIENCE (2003)
Dimerization of the type 4 cAMP-specific phosphodiesterases is mediated by the upstream conserved regions (UCRs)
W Richter et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Cyclic nucleotide research - still expanding after half a century
JA Beavo et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2002)
Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-α responses
SLC Jin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Schizophrenia and affective disorders - Cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: Clinical and P300 findings in a family
DHR Blackwood et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2001)
Phosphodiesterase type 4 isozymes expression in human brain examined by in situ hybridization histochemistry and [3H]rolipram binding autoradiography -: Comparison with monkey and rat brain
S Pérez-Torres et al.
JOURNAL OF CHEMICAL NEUROANATOMY (2000)
Sub-family selective actions in the ability of Erk2 MAP kinase to phosphorylate and regulate the activity of PDE4 cyclic AMP-specific phosphodiesterases
GS Baillie et al.
BRITISH JOURNAL OF PHARMACOLOGY (2000)
Immunosuppressive and anti-inflammatory effects of cyclic AMP phosphodiesterase (PDE) type 4 inhibitors
JE Souness et al.
IMMUNOPHARMACOLOGY (2000)
Share Paper
