Journal
CELLS
Volume 9, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/cells9051102
Keywords
MDPs; mitochondrial-derived peptides; Humanin; HNG; SHLPs; MOTS-c; Age-related Macular Degeneration (AMD); neuroprotection; RPE; mitochondria
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Funding
- Arnold and Mabel Beckman foundation
- NEI [R01 EY0127363]
- Discovery Eye Foundation
- Iris and B. Gerald Cantor Foundation
- Research to Prevent Blindness
- UCI School of Medicine
- Institute for Clinical and Translational Science (ICTS) at University of California Irvine
- 2017 Genentech/ ARVO AMD Translational Research Fellowship
- 2016 RPB pilot research grant
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Substantive evidence demonstrates the contribution of mitochondrial dysfunction in the etiology and pathogenesis of Age-related Macular Degeneration (AMD). Recently, extensive characterization of Mitochondrial-Derived Peptides (MDPs) has revealed their cytoprotective role in several diseases, including AMD. Here we summarize the varied effects of MDPs on cellular and mitochondrial health, which establish the merit of MDPs as therapeutic targets for AMD. We argue that further research to delve into the mechanisms of action and delivery of MDPs may advance the field of AMD therapy.
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