4.6 Review

Therapeutic Advances of Stem Cell-Derived Extracellular Vesicles in Regenerative Medicine

Journal

CELLS
Volume 9, Issue 3, Pages -

Publisher

MDPI
DOI: 10.3390/cells9030707

Keywords

stem cell; extracellular vesicle; tissue damage; regenerative medicine

Categories

Funding

  1. National Natural Science Foundation of China [81871496]
  2. Zhenjiang Key Laboratory of High Technology Research on Exosomes Foundation and Transformation Application [SS-2018003]
  3. Innovation Project for Graduate Student Research of Jiangsu Province [KYCX17_1819]
  4. Technology Development Project of Jiangsu University [20180361]
  5. Priority Academic Program Development of Jiangsu Higher Education Institutions (Phase III)

Ask authors/readers for more resources

Extracellular vesicles (EVs), which are the main paracrine components of stem cells, mimic the regenerative capacity of these cells. Stem cell-derived EVs (SC-EVs) have been used for the treatment of various forms of tissue injury in preclinical trials through maintenance of their stemness, induction of regenerative phenotypes, apoptosis inhibition, and immune regulation. The efficiency of SC-EVs may be enhanced by selecting the appropriate EV-producing cells and cell phenotypes, optimizing cell culture conditions for the production of optimal EVs, and further engineering the EVs produced to transport therapeutic and targeting molecules.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available