Journal
CELLS
Volume 9, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/cells9030707
Keywords
stem cell; extracellular vesicle; tissue damage; regenerative medicine
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Funding
- National Natural Science Foundation of China [81871496]
- Zhenjiang Key Laboratory of High Technology Research on Exosomes Foundation and Transformation Application [SS-2018003]
- Innovation Project for Graduate Student Research of Jiangsu Province [KYCX17_1819]
- Technology Development Project of Jiangsu University [20180361]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (Phase III)
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Extracellular vesicles (EVs), which are the main paracrine components of stem cells, mimic the regenerative capacity of these cells. Stem cell-derived EVs (SC-EVs) have been used for the treatment of various forms of tissue injury in preclinical trials through maintenance of their stemness, induction of regenerative phenotypes, apoptosis inhibition, and immune regulation. The efficiency of SC-EVs may be enhanced by selecting the appropriate EV-producing cells and cell phenotypes, optimizing cell culture conditions for the production of optimal EVs, and further engineering the EVs produced to transport therapeutic and targeting molecules.
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