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George N. Ioannou et al.
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Hierarchical and selective roles of galectins in hepatocarcinogenesis, liver fibrosis and inflammation of hepatocellular carcinoma
Maria L. Bacigalupo et al.
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V. Sanchez-Valle et al.
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FREE RADICAL BIOLOGY AND MEDICINE (2012)
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Toshiaki Teratani et al.
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Deactivation of Hepatic Stellate Cells During Liver Fibrosis Resolution in Mice
Juliane S. Troeger et al.
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NKp46-mediated killing of human and mouse hepatic stellate cells attenuates liver fibrosis
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GUT (2012)
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Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis
Anne Leroux et al.
JOURNAL OF HEPATOLOGY (2012)
Replacement of Retinyl Esters by Polyunsaturated Triacylglycerol Species in Lipid Droplets of Hepatic Stellate Cells during Activation
Nicole Testerink et al.
PLOS ONE (2012)
NADPH Oxidase NOX4 Mediates Stellate Cell Activation and Hepatocyte Cell Death during Liver Fibrosis Development
Patricia Sancho et al.
PLOS ONE (2012)
Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis
Tatiana Kisseleva et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis
Prakash Ramachandran et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Fibrosis is regulated by Th2 and Th17 responses and by dynamic interactions between fibroblasts and macrophages
Luke Barron et al.
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Role of integrins in fibrosing liver diseases
Eleonora Patsenker et al.
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Ursula E. Lee et al.
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY (2011)
Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth
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Nidal Muhanna et al.
GUT (2011)
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Raffaella M. Gadaleta et al.
GUT (2011)
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Yong-Han Paik et al.
HEPATOLOGY (2011)
Characterization of Fecal Microbial Communities in Patients with Liver Cirrhosis
Yanfei Chen et al.
HEPATOLOGY (2011)
Lineage Tracing Demonstrates No Evidence of Cholangiocyte Epithelial-to-Mesenchymal Transition in Murine Models of Hepatic Fibrosis
Andrew S. Chu et al.
HEPATOLOGY (2011)
Fatty Acid and Endotoxin Activate Inflammasomes in Mouse Hepatocytes that Release Danger Signals to Stimulate Immune Cells
Timea Csak et al.
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Pathologic Criteria for Nonalcoholic Steatohepatitis: Interprotocol Agreement and Ability to Predict Liver-Related Mortality
Zobair M. Younossi et al.
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Death Receptor 5 Signaling Promotes Hepatocyte Lipoapoptosis
Sophie C. Cazanave et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Targeted Inhibition of β-Catenin/CBP Signaling Ameliorates Renal Interstitial Fibrosis
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JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2011)
Curcumin protects mice against concanavalin A-induced hepatitis by inhibiting intrahepatic intercellular adhesion molecule-1 (ICAM-1) and CXCL10 expression
Chuan-tao Tu et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2011)
Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling
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NATURE IMMUNOLOGY (2011)
NF-κB in the liver-linking injury, fibrosis and hepatocellular carcinoma
Tom Luedde et al.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2011)
Hepatocytes Do Not Undergo Epithelial-Mesenchymal Transition in Liver Fibrosis in Mice
Kojiro Taura et al.
HEPATOLOGY (2010)
Hepatic Lipotoxicity and the Pathogenesis of Nonalcoholic Steatohepatitis: the Central Role of Nontriglyceride Fatty Acid Metabolites
Brent A. Neuschwander-Tetri
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Evolution of Inflammation in Nonalcoholic Fatty Liver Disease: The Multiple Parallel Hits Hypothesis
Herbert Tilg et al.
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β-Catenin Regulates Mesenchymal Progenitor Cell Differentiation During Hepatogenesis
Tove Berg et al.
JOURNAL OF SURGICAL RESEARCH (2010)
Curcumin limits the fibrogenic evolution of experimental steatohepatitis
Francesco Vizzutti et al.
LABORATORY INVESTIGATION (2010)
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Cheng Liu et al.
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Circulating mitochondrial DAMPs cause inflammatory responses to injury
Qin Zhang et al.
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Vivian Barry-Hamilton et al.
NATURE MEDICINE (2010)
Functional role of chemokines in liver disease models
Hacer Sahin et al.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2010)
Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis.
Arun J. Sanyal et al.
NEW ENGLAND JOURNAL OF MEDICINE (2010)
Inhibition of Wnt/β-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis
William R. Henderson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
The polarization of immune cells in the tumour environment by TGFβ
Richard A. Flavell et al.
NATURE REVIEWS IMMUNOLOGY (2010)
Atorvastatin attenuates angiotensin II-induced inflammatory actions in the liver
Montserrat Moreno et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2009)
Down-regulation of FoxO-dependent c-FLIP expression mediates TRAIL-induced apoptosis in activated hepatic stellate cells
Soo-Jung Park et al.
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Simvastatin Lowers Portal Pressure in Patients With Cirrhosis and Portal Hypertension: A Randomized Controlled Trial
Juan G. Abraldes et al.
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VSL#3 Probiotic Treatment Attenuates Fibrosis Without Changes in Steatohepatitis in a Diet-Induced Nonalcoholic Steatohepatitis Model in Mice
Arumugam Velayudham et al.
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The Etiology of Liver Damage Imparts Cytokines Transforming Growth Factor β1 or Interleukin-13 as Driving Forces in Fibrogenesis
Hong-Lei Weng et al.
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Targeting Liver Fibrosis: Strategies for Development and Validation of Antifibrotic Therapies
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HEPATOLOGY (2009)
Relation Between Liver Progenitor Cell Expansion and Extracellular Matrix Deposition in a CDE-Induced Murine Model of Chronic Liver Injury
Noemi K. M. Van Hul et al.
HEPATOLOGY (2009)
Pan-Caspase Inhibitor VX-166 Reduces Fibrosis in an Animal Model of Nonalcoholic Steatohepatitis
Rafal P. Witek et al.
HEPATOLOGY (2009)
Hepatic Recruitment of the Inflammatory Gr1+ Monocyte Subset Upon Liver Injury Promotes Hepatic Fibrosis
Karlin Raja Karlmark et al.
HEPATOLOGY (2009)
CCR2 Promotes Hepatic Fibrosis in Mice
Ekihiro Seki et al.
HEPATOLOGY (2009)
Adiponectin prevents progression of steatohepatitis in mice by regulating oxidative stress and Kupffer cell phenotype polarization
Juichi Fukushima et al.
HEPATOLOGY RESEARCH (2009)
Function of Nod-like receptors in microbial recognition and host defense
Luigi Franchi et al.
IMMUNOLOGICAL REVIEWS (2009)
NF-kappa B in liver diseases: a target for drug therapy
Pablo Muriel
JOURNAL OF APPLIED TOXICOLOGY (2009)
Pharmacological actions of curcumin in liver diseases or damage
Yadira Rivera-Espinoza et al.
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The global burden of hepatitis C
Daniel Lavanchy
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Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis
Jason H. Cheng et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2008)
Canonical Wnt signaling maintains the quiescent stage of hepatic stellate cells
Claus Kordes et al.
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Immune Interactions in Hepatic Fibrosis
Andrew P. Holt et al.
CLINICS IN LIVER DISEASE (2008)
Silibinin Is a Potent Antiviral Agent in Patients With Chronic Hepatitis C Not Responding to Pegylated Interferon/Ribavirin Therapy
Peter Ferenci et al.
GASTROENTEROLOGY (2008)
Abrogation of the antifibrotic effects of natural killer cells/interferon-gamma contributes to alcohol acceleration of liver fibrosis
Won-Il Jeong et al.
GASTROENTEROLOGY (2008)
Hepatocyte-specific Smad7 expression attenuates TGF-β-mediated fibrogenesis and protects against liver damage
Steven Dooley et al.
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Mechanisms of hepatic fibrogenesis
Scott L. Friedman
GASTROENTEROLOGY (2008)
Farnesoid X Receptor Antagonizes Nuclear Factor κB in Hepatic Inflammatory Response
Yan-Dong Wang et al.
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Eiichiro Yamamoto et al.
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Pablo Muriel et al.
JOURNAL OF APPLIED TOXICOLOGY (2008)
Lysyl Oxidase Binds Transforming Growth Factor-β and Regulates Its Signaling via Amine Oxidase Activity
Phimon Atsawasuwan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Lysyl oxidase oxidizes cell membrane proteins and enhances the chemotactic response of vascular smooth muscle cells
Hector A. Lucero et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Leukocyte adhesion in the liver: Distinct adhesion paradigm from other organs
Woo-Yong Lee et al.
JOURNAL OF HEPATOLOGY (2008)
Effects of silymarin on the resolution of liver fibrosis induced by carbon tetrachloride in rats
J. H. Tsai et al.
JOURNAL OF VIRAL HEPATITIS (2008)
Hepatic fibrogenesis in response to chronic liver injury: novel insights on the role of cell-to-cell interaction and transition
Gianluca Svegliati-Baroni et al.
LIVER INTERNATIONAL (2008)
Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone
Yasushi Sato et al.
NATURE BIOTECHNOLOGY (2008)
Hepatic stellate cells: Protean, multifunctional, and enigmatic cells of the liver
Scott L. Friedman
PHYSIOLOGICAL REVIEWS (2008)
Exploring the full spectrum of macrophage activation
David M. Mosser et al.
NATURE REVIEWS IMMUNOLOGY (2008)
Analysis of silibinin in rat plasma and bile for hepatobiliary excretion and oral bioavailability application
Jhy-Wen Wu et al.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2007)
Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll-like receptor 9
Azuma Watanabe et al.
HEPATOLOGY (2007)
Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition
Michael Zeisberg et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Progressive fibrosis in nonalcoholic steato hepatitis: Association with altered regeneration and a ductular reaction
Michelle M. Richardson et al.
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Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients
Junliang Fu et al.
GASTROENTEROLOGY (2007)
Liver fibrosis in vitro:: Cell culture models and precision-cut liver slices
M. Van de Bovenkamp et al.
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Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE
Jane Tian et al.
NATURE IMMUNOLOGY (2007)
Lymphocyte-hepatic stellate cell proximity suggests a direct interaction
N. Muhanna et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2007)
Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis
Jonathan A. Fallowfield et al.
JOURNAL OF IMMUNOLOGY (2007)
Prominent contribution of portal mesenchymal cells to liver fibrosis in ischemic and obstructive cholestatic injuries
Marc Beaussier et al.
LABORATORY INVESTIGATION (2007)
Emerging insights into transforming growth factor β Smad signal in hepatic fibrogenesis
Y. Inagaki et al.
GUT (2007)
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John P. Iredale
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The effect of a silybin-vitamin E-phospholipid complex on nonalcoholic fatty liver disease: A pilot study
Carmela Loguercio et al.
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Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α
Marie Lagouge et al.
CELL (2006)
Resveratrol improves health and survival of mice on a high-calorie diet
Joseph A. Baur et al.
NATURE (2006)
TLR4 links innate immunity and fatty acid-induced insulin resistance
Hang Shi et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis
Tatiana Kisseleva et al.
JOURNAL OF HEPATOLOGY (2006)
Liver fibrosis induced by hepatic overexpression of PDGF-B in transgenic mice
Piotr Czochra et al.
JOURNAL OF HEPATOLOGY (2006)
Anti-fibrotic activity of NK cells in experimental liver injury through killing of activated HSC
Alaa Melhem et al.
JOURNAL OF HEPATOLOGY (2006)
Transport of galectin-3 between the nucleus and cytoplasm. I. Conditions and signals for nuclear import
Peter J. Davidson et al.
GLYCOBIOLOGY (2006)
Hepatocyte growth factor attenuates liver fibrosis induced by bile duct ligation
JL Xia et al.
AMERICAN JOURNAL OF PATHOLOGY (2006)
Mechanisms of liver injury. III. Oxidative stress in the pathogenesis of hepatitis C virus
J Choi et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2006)
Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo
SS Zhan et al.
HEPATOLOGY (2006)
Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners
S Radaeva et al.
GASTROENTEROLOGY (2006)
Smad3 specific inhibitor, naringenin, decreases the expression of extracellular matrix induced by TGF-beta 1 in cultured rat hepatic stellate cells
XJ Liu et al.
PHARMACEUTICAL RESEARCH (2006)
Hepatitis C virus core protein inhibits mitochondrial electron transport and increases reactive oxygen species (ROS) production
M Korenaga et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Attenuated liver fibrosis in the absence of B cells
TI Novobrantseva et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Protective effect of selenium-enriched lactobacillus on CCl4-induced liver injury in mice and its possible mechanisms
Long Chen et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2005)
The Farnesoid X receptor - A molecular link between bile acid and lipid and glucose metabolism
T Claudel et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2005)
Expression patterns of PDGF-A, -B, -C and -D and the PDGF-receptors α and β in activated rat hepatic stellate cells (HSC)
K Breitkopf et al.
CYTOKINE (2005)
CXCR3 activation promotes lymphocyte transendothelial migration across human hepatic endothelium under fluid flow
SM Curbishley et al.
AMERICAN JOURNAL OF PATHOLOGY (2005)
Early response of α2(I) collagen to acetaldehyde in human hepatic stellate cells is TGF-β independent
G Svegliati-Baroni et al.
HEPATOLOGY (2005)
Hepatitis C virus-replicating hepatocytes induce fibrogenic activation of hepatic stellate cells
A Schulze-Krebs et al.
GASTROENTEROLOGY (2005)
The type of collagen cross-link determines the reversibility of experimental skin fibrosis
AJ van der Slot-Verhoeven et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2005)
The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion
A Tsung et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
Binding of hepatitis C virus envelope protein E2 to CD81 up-regulates matrix metalloproteinase-2 in human hepatic stellate cells
A Mazzocca et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma
JS Campbell et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
JS Duffield et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
A significant proportion of myofibroblasts are of bone marrow origin in human liver fibrosis
SJ Forbes et al.
GASTROENTEROLOGY (2004)
Peroxisome proliferator-activated receptor γ induces a phenotypic switch from activated to quiescent hepatic stellate cells
S Hazra et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Autocrine release of TGF-β by portal fibroblasts regulates cell growth
RG Wells et al.
FEBS LETTERS (2004)
Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells
R Bataller et al.
GASTROENTEROLOGY (2004)
Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes
R Safadi et al.
GASTROENTEROLOGY (2004)
A small molecule inhibitor of β-catenin/cyclic AMP response element-binding protein transcription
KH Emami et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Fibrotic disease and the TH1/TH2 paradigm
TA Wynn
NATURE REVIEWS IMMUNOLOGY (2004)
A hepatitis C virus-encoded, nonstructural protein (NS3) triggers dysfunction and apoptosis in lymphocytes:: role of NADPH oxidase-derived oxygen radicals
F Thorén et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2004)
Nomenclature of the finer branches of the biliary tree: Canals, ductules, and ductular reactions in human livers
TA Roskams et al.
HEPATOLOGY (2004)
The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis
S Fiorucci et al.
GASTROENTEROLOGY (2004)
Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression
A Canbay et al.
HEPATOLOGY (2003)
TNF-α-induced cell death in ethanol-exposed cells depends on p38 MAPK signaling but is independent of bid and caspase-8
JG Pastorino et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2003)
Enhancing mechanical properties of tissue-engineered constructs via lysyl oxidase crosslinking activity
WM Elbjeirami et al.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2003)
Hepatocyte apoptosis and Fas expression are prominent features of human nonalcoholic steatohepatitis
AE Feldstein et al.
GASTROENTEROLOGY (2003)
Activated human hepatic stellate cells express the renin-angiotensin system and synthesize angiotensin II
R Bataller et al.
GASTROENTEROLOGY (2003)
Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease
ZP Li et al.
HEPATOLOGY (2003)
Exploring the biological basis of hepatitis B e antigen in hepatitis B virus infection
D Milich et al.
HEPATOLOGY (2003)
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