Journal
CELLS
Volume 9, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/cells9041011
Keywords
cancer; myeloid-derived suppressor cells; MDSCs; metabolism signaling pathway; immune cell differentiation; tumor immunotherapy; immunotherapy; cell differentiation
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Funding
- National Natural Science Foundation for Key Programs of China [31730024]
- National Natural Science Foundation for General Programs of China [31671524]
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Myeloid-derived suppressor cells (MDSCs) are a group of immunosuppressive cells that play crucial roles in promoting tumor growth and protecting tumors from immune recognition in tumor-bearing mice and cancer patients. Recently, it has been shown that the metabolic activity of MDSCs plays an important role in the regulation of their inhibitory function, especially in the processes of tumor occurrence and development. The MDSC metabolism, such as glycolysis, fatty acid oxidation and amino acid metabolism, is rewired in the tumor microenvironment (TME), which enhances the immunosuppressive activity, resulting in effector T cell apoptosis and suppressive cell proliferation. Herein, we summarized the recent progress in the metabolic reprogramming and immunosuppressive function of MDSCs during tumorigenesis.
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