Journal
CELLS
Volume 9, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/cells9040837
Keywords
alcohol; autophagy; mitochondria; NAFLD; Parkin; Pink1
Categories
Funding
- National Institute on Alcohol Abuse and Alcoholism [R01 AA020518, U01 AA024733, R21 AA027250]
- National Institute of Diabetes and Digestive and Kidney Diseases [R01 DK102142]
- Nathan Shock Center [P30 AG050886]
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The mitochondrion is an organelle that plays a vital role in the regulation of hepatic cellular redox, lipid metabolism, and cell death. Mitochondrial dysfunction is associated with both acute and chronic liver diseases with emerging evidence indicating that mitophagy, a selective form of autophagy for damaged/excessive mitochondria, plays a key role in the liver's physiology and pathophysiology. This review will focus on mitochondrial dynamics, mitophagy regulation, and their roles in various liver diseases (alcoholic liver disease, non-alcoholic fatty liver disease, drug-induced liver injury, hepatic ischemia-reperfusion injury, viral hepatitis, and cancer) with the hope that a better understanding of the molecular events and signaling pathways in mitophagy regulation will help identify promising targets for the future treatment of liver diseases.
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