Journal
CELLS
Volume 9, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/cells9051118
Keywords
IAP; ubiquitination; cell signaling; inflammation
Categories
Funding
- La Ligue contre le cancer Comite de la Cote d'Or
- Conseil Regional de Bourgogne-Franche-Comte
- French National research Agency, (Investissements d'Avenir program) [ANR-11-LABX-0021]
- European Union program FEDER
- Ministere de l'Enseignement Superieur et de la Recherche of France
- Fondation ARC
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Over the last decade, the E3-ubiquitine ligases from IAP (Inhibitor of Apoptosis) family have emerged as potent regulators of immune response. In immune cells, they control signaling pathways driving differentiation and inflammation in response to stimulation of tumor necrosis factor receptor (TNFR) family, pattern-recognition receptors (PRRs), and some cytokine receptors. They are able to control the activity, the cellular fate, or the stability of actors of signaling pathways, acting at different levels from components of receptor-associated multiprotein complexes to signaling effectors and transcription factors, as well as cytoskeleton regulators. Much less is known about ubiquitination substrates involved in non-immune signaling pathways. This review aimed to present IAP ubiquitination substrates and the role of IAP-mediated ubiquitination in regulating signaling pathways.
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