4.6 Article

Cancer-Selective Treatment of Cancerous and Non-Cancerous Human Cervical Cell Models by a Non-Thermally Operated Electrosurgical Argon Plasma Device

Journal

CANCERS
Volume 12, Issue 4, Pages -

Publisher

MDPI
DOI: 10.3390/cancers12041037

Keywords

non-thermal plasma; high frequency electrosurgery; plasma treatment; cold atmospheric plasma (CAP); free radicals; reactive species; cancer selectivity; cervical cancer treatment; cervical intraepithelial neoplasia

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Funding

  1. Faculty of Medicine of the Eberhard Karls University Tubingen [2432-1-0, 417-0-0]

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Cold atmospheric plasma (CAP) treatment is developing as a promising option for local anti-neoplastic treatment of dysplastic lesions and early intraepithelial cancer. Currently, high-frequency electrosurgical argon plasma sources are available and well established for clinical use. In this study, we investigated the effects of treatment with a non-thermally operated electrosurgical argon plasma source, a Martin Argon Plasma Beamer System (MABS), on cell proliferation and metabolism of a tissue panel of human cervical cancer cell lines as well as on non-cancerous primary cells of the cervix uteri. Similar to conventional CAP sources, we were able to show that MABS was capable of causing antiproliferative and cytotoxic effects on cervical squamous cell and adenocarcinoma as well as on non-neoplastic cervical tissue cells due to the generation of reactive species. Notably, neoplastic cells were more sensitive to the MABS treatment, suggesting a promising new and non-invasive application for in vivo treatment of precancerous and cancerous cervical lesions with non-thermally operated electrosurgical argon plasma sources.

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