Journal
JOURNAL OF CLINICAL MEDICINE
Volume 9, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/jcm9040966
Keywords
autism spectrum disorder; genetic; epigenetic; etiology
Categories
Funding
- National Research Foundation of Korea (NRF) - Korea government (MSIT) of the Republic of Korea [2016M3A9B6946835, 2015R1A5A1009701]
- National Research Foundation of Korea [2016M3A9B6946835] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Ask authors/readers for more resources
Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder characterized by difficulties in social interaction, language development delays, repeated body movements, and markedly deteriorated activities and interests. Environmental factors, such as viral infection, parental age, and zinc deficiency, can be plausible contributors to ASD susceptibility. As ASD is highly heritable, genetic risk factors involved in neurodevelopment, neural communication, and social interaction provide important clues in explaining the etiology of ASD. Accumulated evidence also shows an important role of epigenetic factors, such as DNA methylation, histone modification, and noncoding RNA, in ASD etiology. In this review, we compiled the research published to date and described the genetic and epigenetic epidemiology together with environmental risk factors underlying the etiology of the different phenotypes of ASD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available