Journal
EBIOMEDICINE
Volume 54, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ebiom.2020.102724
Keywords
Artificial intelligence; Computed tomography; Automatic pulmonary scanning; Interstitial lung disease; Radiation exposure
Funding
- National Natural Science Foundation of China [81720108022, 91649116, 81571040, 81973145]
- Social Development Project of Science and Technology in Jiangsu Province [BE2016605, BE201707]
- National Key R&D Program of China [2017YFC0112801]
- Key Medical Talents of Jiangsu Province
- '13th Five-Year' Health Promotion Project of Jiangsu Province (B.Z.2016-2020)
- Jiangsu Provincial Key Medical Discipline (Laboratory) [ZDXKA2016020]
- Project of the Sixth Peak of Talented People [WSN-138]
- China Postdoctoral Science Foundation [2019M651805]
- Double First-Class University project [CPU2018GY09]
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Background: Interstitial lung disease requires frequent re-examination, which directly causes excessive cumulative radiation exposure. To date, Al has not been applied to CT for enhancing clinical care; thus, we hypothesize Al may empower CT with intelligence to realize automatic and accurate pulmonary scanning, thus dramatically decrease medical radiation exposure without compromising patient care. Methods: Facial boundary detection was realized by recognizing adjacent jaw position through training and testing a region proposal network (RPN) on 76,882 human faces using a preinstalled 2-dimensional camera; the lung-fields was then segmented by V-Net on another training set with 314 subjects and calculated the moving distance of the scanning couch based on a pre-generated calibration table. A multi-cohort study, including 1,186 patients was used for validation and radiation dose quantification under three clinical scenarios. Findings: A U-HAPPY (United imaging Human Automatic Planbox for Pulmonary) scanning CT was designed. Error distance of RPN was 4.46 +/- 0.02 pixels with a success rate of 98.7% in training set and 2.23 +/- 0.10 pixels with 100% success rate in testing set. Average Dice's coefficient was 0.99 in training set and 0.96 in testing set. A calibration table with 1,344,000 matches was generated to support the linkage between camera and scanner. This real-time automation makes an accurate plan-box to cover exact location and area needed to scan, thus reducing amounts of radiation exposures significantly (all, P<0.001). Interpretation: U-HAPPY CT designed for pulmonary imaging acquisition standardization is promising for reducing patient risk and optimizing public health expenditures. (C) 2020 The Author(s). Published by Elsevier B.V.
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