Journal
SCIENCE ADVANCES
Volume 6, Issue 15, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.aay0076
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Funding
- NIH under Ruth L. Kirschstein National Research Service Award from the National Institute of General Medical Sciences [2T32GM008267]
- Knight Family Foundation Graduate Research Fellowship in Nanoscience and Technology
- Samuel C. Fleming Family Graduate Fellowship
- Kavli Institute at Cornell Postdoctoral fellowship
- National Institute of Arthritis and Musculoskeletal and Skin Diseases [K08AR068469]
- National Cancer Institute [R33-CA193043, U54 CA210184]
- Division of Materials Sciences and Engineering Sciences, Office of Basic Energy Sciences, U.S. Department of Energy [DEFG02-07ER46463]
- Cornell University Biotechnology Resource Center (BRC) Imaging Facility [NIH S10OD018516]
- NSF [ECCS-1542081]
- NSF MRSEC program [DMR-1120296]
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Silicones are commonly used for lubrication of syringes, encapsulation of medical devices, and fabrication of surgical implants. While silicones are generally viewed as relatively inert to the cellular milieu, they can mediate a variety of inflammatory responses and other deleterious effects, but the mechanisms underlying the bioactivity of silicones remain unresolved. Here, we report that silicone liquids and gels have high surface stresses that can strongly resist deformation at cellular length scales. Biomedical silicones, including syringe lubricants and fillings from FDA-approved breast implants, readily adsorb matrix proteins and activate canonical rigidity sensing pathways through their surface stresses. In 3D culture models, liquid silicone droplets support robust cellular adhesion and the formation of multinucleated monocyte-derived cell masses that recapitulate phenotypic aspects of granuloma formation in the foreign body response. Together, our findings implicate surface stress as a cellular stimulant that should be considered in application of silicones for biomedical purposes.
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