Journal
SCIENCE ADVANCES
Volume 6, Issue 15, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.aay5969
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Funding
- Bill & Melinda Gates Foundation [BMGF 47075]
- Foundation for the National Institutes of Health
- BMGF [OPP1066146, OPP1152146]
- Sherrilyn and Ken Fisher Center for Environmental Infectious Diseases of the Johns Hopkins School of Medicine
- National Institutes of Health, Fogarty International Center
- BBSRC [BB/M006484/1, BB/S013997/1] Funding Source: UKRI
- Bill and Melinda Gates Foundation [OPP1152146] Funding Source: Bill and Melinda Gates Foundation
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Malnutrition continues to affect the growth and development of millions of children worldwide, and chronic under-nutrition has proven to be largely refractory to interventions. Improved understanding of metabolic development in infancy and how it differs in growth-constrained children may provide insights to inform more timely, targeted, and effective interventions. Here, the metabolome of healthy infants was compared to that of growth-constrained infants from three continents over the first 2 years of life to identify metabolic signatures of aging. Predictive models demonstrated that growth-constrained children lag in their metabolic maturity relative to their healthier peers and that metabolic maturity can predict growth 6 months into the future. Our results provide a metabolic framework from which future nutritional programs may be more precisely constructed and evaluated.
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