Journal
SCIENCE ADVANCES
Volume 6, Issue 12, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.aaz0007
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Funding
- UCLA Henry Samueli School of Engineering and Applied Sciences
- National Science Foundation [1847729]
- Henry M. Jackson Foundation
- Stanford Genome Technology Center Distinguished Young Investigator Award (Intermountain Healthcare)
- Brain and Behavior Foundation (NARSAD Young Investigator Grant)
- PhRMA Foundation (Research Starter Grant in Translational Medicine and Therapeutics)
- Directorate For Engineering
- Div Of Electrical, Commun & Cyber Sys [1847729] Funding Source: National Science Foundation
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To render high-fidelity wearable biomarker data, understanding and engineering the information delivery pathway from epidermally retrieved biofluid to a readout unit are critical. By examining the biomarker information delivery pathway and recognizing near-zero strained regions within a microfluidic device, a strain-isolated pathway to preserve biomarker data fidelity is engineered. Accordingly, a generalizable and disposable freestanding electrochemical sensing system (FESS) is devised, which simultaneously facilitates sensing and out-of-plane signal interconnection with the aid of double-sided adhesion. The FESS serves as a foundation to realize a system-level design strategy, addressing the challenges of wearable biosensing, in the presence of motion, and integration with consumer electronics. To this end, a FESS-enabled smartwatch was developed, featuring sweat sampling, electrochemical sensing, and data display/transmission, all within a self-contained wearable platform. The FESS-enabled smartwatch was used to monitor the sweat metabolite profiles of individuals in sedentary and high-intensity exercise settings.
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