Journal
ARCHIVES OF ENDOCRINOLOGY METABOLISM
Volume 64, Issue 4, Pages 436-444Publisher
SBEM-SOC BRASIL ENDOCRINOLOGIA & METABOLOGIA
DOI: 10.20945/2359-3997000000230
Keywords
Vitamin K intake; phylloquinone; body fat; lipid profile; glucose homeostasis
Categories
Funding
- National Council for Scientific and Technological Development (CNPq) [153369/2016-7]
- Sao Paulo State Foundation for Research Support [Fapesp 2012-22113-9]
- State Secretariat of Health of Sao Paulo [2013-0.235.936.0]
- Fapesp [15/07971-7]
- National Council for Scientific and Technological Development [CNPq 402674/2016-2]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [15/07971-7] Funding Source: FAPESP
Ask authors/readers for more resources
Objective: Recent research has investigated the possible inverse relationship between vitamin K intake and body fat. In addition, an increasing number of studies are supporting a key role for this vitamin in improving lipid profile and insulin sensitivity and reducing the risk of type 2 diabetes mellitus, but little is known about what mechanisms would be involved. Thus, the objective of this study was to investigate the relationship between vitamin K intake (in the form of phylloquinone - PK), body fat, lipid profile and markers of glucose homeostasis in adults and the elderly. Subjects and methods: A cross-sectional study with 298 participants (46% men) in the Sao Paulo Health Survey 2014-2015. Spearman correlations were performed to evaluate the associations between vitamin K intake and the biochemical and body composition measures. Results: Among normal-weight male adults (n = 15), PK intake presented a positive correlation with the quantitative insulin sensitivity check index (QUICKI) (r = 0.525; p = 0.045). Among men with high fat mass index (FMI) (n = 101), PK intake had a negative correlation with homeostasis model assessment estimate for beta-cell function (HOMA-beta) (r = -0.227; p = 0.022). In women with high FMI (n = 122), PK intake had a negative correlation with HOMA-beta (r = -0.199, p = 0.032) and insulin (r = -0.207, p = 0.026). No correlations were found between PK intake and lipid profile. Conclusions: Our findings support a potential relationship among PK intake, body fat and markers of glucose homeostasis in adults and the elderly.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available