Journal
MATERIALS RESEARCH LETTERS
Volume 8, Issue 6, Pages 239-246Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/21663831.2020.1744758
Keywords
Cell proliferation; grain boundary density; ultrafine grain titanium
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Funding
- National Center for Research Resources [5P20RR016480-12]
- National Institute of General Medical Sciences [8 P20 GM103451-12]
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IMPACT STATEMENT By eliminating the influences of texture and roughness we have isolated the positive correlation between MC3TE-E1 cell proliferation on titanium and grain boundary length per surface-attached cell. Studies since 2004 have shown that the cytocompatibility of ultrafine grain (UG) commercial purity (CP) titanium exceeds that of coarse grain (CG) CP titanium (Ti) by 30% to 20-fold. To isolate the factors affecting this large reported variability of CP titanium's cytocompatibility, discs of UG and CG titanium were fabricated with controlled texture and roughness. The discs were seeded with MC3T3-E1 pre-osteoblastic cells and cultured for 72 h. The proliferation of cells on polished UG-Ti exceeded unpolished CG-Ti 3.04-fold. Cell proliferation was found to correlate with a new biophysical parameter, the average grain boundary length per surface-attached cell.
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