Journal
REDOX BIOLOGY
Volume 34, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.redox.2020.101475
Keywords
NRF2; Heavy metals; Pesticides; Air pollutants; Epigenetic modi fications; Redox signaling pathways
Categories
Funding
- National Institutes of Health [R01ES07331, R01ES10563]
- National Natural Science Foundation of China [81573195, 81903352, 81973083]
- Joint Funds for the Innovation of Science and Technology, Fujian province [2017Y9105]
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [18H05293, 17K15489]
- Grants-in-Aid for Scientific Research [17K15489] Funding Source: KAKEN
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Living organisms are surrounded with heavy metals such as methylmercury, manganese, cobalt, cadmium, ar-senic, as well as pesticides such as deltamethrin and paraquat, or atmospheric pollutants such as quinone. Extensive studies have demonstrated a strong link between environmental pollutants and human health. Redox toxicity is proposed as one of the main mechanisms of chemical-induced pathology in humans. Acting as both a sensor of oxidative stress and a positive regulator of antioxidants, the nuclear factor erythroid 2-related factor 2 (NRF2) has attracted recent attention. However, the role NRF2 plays in environmental pollutant-induced toxicity has not been systematically addressed. Here, we characterize NRF2 function in response to various pollutants, such as metals, pesticides and atmospheric quinones. NRF2 related signaling pathways and epigenetic regula-tions are also reviewed.
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