Journal
FRONTIERS IN IMMUNOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2020.00470
Keywords
Tcf7; TCF-1; enhancer; T cells; innate lymphoid cells; development
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Funding
- Intramural Research Program of the National Institutes of Health, National Cancer Institute , and Center for Cancer Research
- Fondation pour la Recherche Medicale [DEQ20170839118]
- National Research Agency Investissements d'Avenir via the program LabEX IGO [ANR-11-LABX-0016-01]
- NATIONAL CANCER INSTITUTE [ZIABC011633] Funding Source: NIH RePORTER
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The transcription factor TCF-1 (encoded by Tcf7) plays critical roles in several lineages of hematopoietic cells. In this study, we examined the molecular basis for Tcf7 regulation in T cells, innate lymphoid cells, and migratory conventional dendritic cells that we find express Tcf7. We identified a 1 kb regulatory element crucial for the initiation of Tcf7 expression in T cells and innate lymphoid cells, but dispensable for Tcf7 expression in Tcf7-expressing dendritic cells. Within this region, we identified a Notch binding site important for the initiation of Tcf7 expression in T cells but not in innate lymphoid cells. Our work establishes that the same regulatory element is used by distinct transcriptional controllers to initiate Tcf7 expression in T cells and ILCs.
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