Journal
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
Volume 21, Issue 1, Pages 145-155Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1871530320666200503051609
Keywords
Allergic airway disease; biochanin A; IgE; inflammation; isoflavones; PPAR gamma
Funding
- Science & Engineering Research Board (SERB) [EMR/2017/000973]
- Department of Science & Technology, Government of India
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BCA can alleviate inflammation in a murine model of asthma by activating PPAR gamma, showing promise for the treatment of asthma in humans.
Objective: Asthma is an inflammatory airway disease affecting most of the population in the world. The current medication for asthma relieves airway inflammation but it has serious adverse effects. Biochanin A (BCA), a phytoestrogen, is an active component present in red clover, alfalfa, soy having anti-oxidant and anti-inflammatory properties. BCA was identified as a natural activator of peroxisome proliferator-activated receptor-gamma (PPAR gamma). Methods: The study aims to evaluate the effects of BCA in ovalbumin (OVA)-induced murine model of asthma and to study the role of PPAR gamma. Results: We found that BCA administration reduced the severity of murine allergic asthma as evidenced histologically, and measurement of allergen-specific IgE levels in serum as well as in BAL fluid. BCA also reversed the elevated levels of inflammatory cytokines, cell infiltration, protein leakage into the airways and expression of hemoxygenase-1 in OVA-induced lungs. Further, we confirmed that BCA mediated inhibitory effects are mediated through PPAR gamma as assessed by treatment with PPAR gamma antagonist GW9662. Conclusion: Our results suggest that BCA is efficacious in a preclinical model of asthma and may have the potential for the treatment of asthma in humans.
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