4.6 Review

Implantable anti-angiogenic scaffolds for treatment of neovascular ocular pathologies

Journal

DRUG DELIVERY AND TRANSLATIONAL RESEARCH
Volume 10, Issue 5, Pages 1191-1202

Publisher

SPRINGER HEIDELBERG
DOI: 10.1007/s13346-020-00753-0

Keywords

Pathological neovascularization; Age-related macular degeneration; Diabetic retinopathy; Self-assembly; Hydrogel; Peptide nanofibers; Anti-angiogenic materials

Funding

  1. NIH [R15 EY029504]
  2. NSF [IIP 1903617]
  3. NJIT Undergraduate Research and Innovation (URI) Program
  4. NJIT Startup funds

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The retinal physiology can accrue oxidative damage and inflammatory insults due to age and metabolic irregularities. Two notable diseases that involve retinal and choroidal neovascularization are proliferative diabetic retinopathy and wet age-related macular degeneration. Currently, these diseases are mainly treated with anti-VEGF drugs (VEGF = vascular endothelial growth factor), generally on a monthly dosage scheme. We discuss recent developments for the treatment of these diseases, including bioactive tissue-engineered materials, which may reduce frequency of dosage and propose a path forward for improving patient outcomes. Graphical abstract Development of materials for long-term intravitreal delivery for management of posterior segment diseases

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