Journal
ADVANCED SCIENCE
Volume 7, Issue 12, Pages -Publisher
WILEY
DOI: 10.1002/advs.201902933
Keywords
cancer treatment; magnetic fields; magnetic nanoparticles; reactive oxygen species; synergistic effects
Categories
Funding
- NSFC [31870997, 81571803]
- Thousand Talents Plan
- Shanghai Municipal Education Commission Innovative Program [2017-01-07-00-07-E00038]
- Shanghai Science and International Cooperation Program [16410724300]
- Fundamental Research Funds for the Central Universities
- Shanghai Tongji University Education Development Foundation
- Shanghai Blue Cross Brain Hospital Co., Ltd
- NIH [R35CA197725]
Ask authors/readers for more resources
Reactive oxygen species (ROS), a group of oxygen derived radicals and derivatives, can induce cancer cell death via elevated oxidative stress. A spatiotemporal approach with safe and deep-tissue penetration capabilities to elevate the intracellular ROS level is highly desirable for precise cancer treatment. Here, a mechanical-thermal induction therapy (MTIT) strategy is developed for a programmable increase of ROS levels in cancer cells via assembly of magnetic nanocubes integrated with alternating magnetic fields. The magneto-based mechanical and thermal stimuli can disrupt the lysosomes, which sequentially induce the dysfunction of mitochondria. Importantly, intracellular ROS concentrations are responsive to the magneto-triggers and play a key role for synergistic cancer treatment. In vivo experiments reveal the effectiveness of MTIT for efficient eradication of glioma and breast cancer. By remote control of the force and heat using magnetic nanocubes, MTIT is a promising physical approach to trigger the biochemical responses for precise cancer treatment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available