Journal
ACS INFECTIOUS DISEASES
Volume 6, Issue 7, Pages 1615-1623Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsinfecdis.0c00050
Keywords
lactoferrin; streptococcus; infection; innate immunity; antimicrobial; nutritional immunity; iron; bacteria; pathogenesis; virulence; infectious disease
Categories
Funding
- National Institutes of Health [R01 HD090061]
- Office of Medical Research, Department of Veterans Affairs [IK2BX001701]
- NIH [T32 HL007411-36S1, GM05551, R35GM133602, R01AI134036]
- National Science Foundation [1547757, 1400969]
- March of Dimes
- Vanderbilt University Medical Center's Digestive Disease Research Center - NIH [P30DK058404]
- Vanderbilt Institute for Clinical and Translational Research program - National Center for Research Resources [UL1 RR024975-01]
- National Center for Advancing Translational Sciences [2 UL1 TR000445-06]
- Direct For Education and Human Resources
- Division Of Human Resource Development [1400969] Funding Source: National Science Foundation
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Streptococcal species are Gram-positive bacteria responsible for a variety of disease outcomes including pneumonia, meningitis, endocarditis, erysipelas, necrotizing fasciitis, periodontitis, skin and soft tissue infections, chorioamnionitis, premature rupture of membranes, preterm birth, and neonatal sepsis. In response to streptococcal infections, the host innate immune system deploys a repertoire of antimicrobial and immune modulating molecules. One important molecule that is produced in response to streptococcal infections is lactoferrin. Lactoferrin has antimicrobial properties including the ability to bind iron with high affinity and sequester this important nutrient from an invading pathogen. Additionally, lactoferrin has the capacity to alter the host inflammatory response and contribute to disease outcome. This Review presents the most recent published work that studies the interaction between the host innate immune protein lactoferrin and the invading pathogen, Streptococcus.
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