Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 6, Issue 6, Pages 3361-3374Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.9b01709
Keywords
halloysite nanotubes; polypyrrole; chemo-photothermal therapy; magnetic targeted; breast cancer
Categories
Funding
- National Natural Science Foundation of China [51502113, 81622050, 81873209]
- Guangdong Basic and Applied Basic Research Foundation [2019A1515011509]
- Fundamental Research Funds for the Central Universities [21619102]
- Science and Technology Program of Guangzhou [201903010062]
- Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program [2017BT01Y036]
- GDUPS (2019)
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Multifunctional nanoparticles for imaging and treatment in cancer are getting more and more attention recently. Herein, halloysite nanotubes (HNTs), natural clay nanotubes, are designed as multifunctional nanoplatform for targeted delivering photothermal therapy agents and chemotherapeutic drugs. Fe3O4 was anchored on the outer surfaces of HNTs and then doxorubicin (DOX) was loaded on the nanotubes. Afterward, a layer of polypyrrole (PPy), as photothermal agent, was wrapped on the tubes. The nanoplatform of HNT@Fe3O4@PPy@DOX can be guided to tumor tissue by an external magnetic field, and then performs chemo-photothermal combined therapy by 808 nm laser irradiation. HNT@Fe3O4@PPy@DOX shows the ability of T-2-weighted magnetic resonance imaging, which could be considered as a promising application in magnetic targeting tumor therapy. In vitro and in vivo experiments demonstrate that HNTs nanoplatform has good biocompatibility and produces a strong antitumor effect trigged by near-infrared laser irradiation. The novel chemo-photothermal therapy nanoplatform based on HNTs may be developed as a multifunctional nanoparticle for imaging and therapy in breast cancer.
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