Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 6, Issue 5, Pages 3154-3161Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.0c00104
Keywords
Antibacterial capacity; Electrospinning; Silk fibroin; Ammonium chloride; Tissue engineering
Categories
Funding
- National Key Research and Development Program of China [2016YFA0201700, 2016YFA0201702, 2018YFC1105800]
- Fundamental Research Funds for the Central Universities [2232019D3-02, 2232019A3-06]
- National Natural Science Foundation of China [21674018, 51903045, 81671451, 81974085]
- International Cooperation Fund of the Science and Technology Commission of Shanghai Municipality [19520744500]
- Natural Science Foundation of Shanghai [18ZR1429200]
- Opening Project of Key Laboratory of Zhejiang Province of China [MTC2019-08]
- Public Welfare Technology Project of Zhejiang Province of China [LGG20E030009]
- Jiaxing Science and Technology Project of Zhejiang of China [2019 AD32008]
- Shanghai Belt and Road Joint Laboratory of Advanced Fiber and Low-Dimension Materials [18520750400]
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Antibacterial scaffolds are highly desirable for the repair and reconstruction of injured soft tissues. However, the direct fabrication of scaffolds with excellent biocompatibility, flexibility, and antibacterial capacity remains a challenge, especially those based on biomaterials. In this study, we report the biomaterial-based antibacterial scaffolds based on regenerated silk fibroin, 2-hydroxypropyltrimethyl ammonium chloride chitosan, and bladder acellular matrix graft by blend and coaxial electrospinning. This approach eliminated the use of organic solvents and inorganic nanoparticles, ensuring greater clinical safety, mimicking physiological extracellular matrix structures, and the required softness for a suture material. Thus, the scaffold obtained in this study exhibited excellent biocompatibility, the required mechanical characteristics, and excellent antibacterial capacity. The rate of bacterial elimination of Staphylococcus aureus and Escherichia coli reached up to 99.5 and 98.3%, respectively. The scaffold design favored cell growth and proliferation and resulted in the significant promotion of repair and reconstruction of the urethra, indicating that it can be an ideal antibacterial suture material for soft tissue restoration.
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