Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 6, Issue 4, Pages 2186-2197Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.0c00195
Keywords
zeolitic imidazolate framework-8; risedronate; drug delivery system; nanoparticles; bone regeneration
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Funding
- National Natural Science Foundation of China [81970984, 81601613, 81771122, 81970985]
- Key Research and Development Project of Sichuan Province [2018SZ0037]
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Bisphosphonates (BPs) are routinely administered for the treatment of turnover bone diseases. To avoid the undesirable adverse effects of long-term usage of bisphosphonates and improve their bioavailability in the bone microenvironment, we initially encapsulated risedronate (RIS) molecules inside nanoscale zeolitic imidazolate framework-8 particles (nZIF-8) by a one-step synthesis method to generate RIS@ZIF-8 nanoparticles. RIS@ZIF-8 nanoparticles displayed high loading encapsulation efficiency (64.21 +/- 2.48%), good biocompatibility, controlled drug release capacity, and dual effects for bone regeneration. This work explored the potential of RIS@ZIF-8 nanoparticles, which could not only enhance ATP production, induce extracellular matrix (ECM) mineralization, and upregulate the expression levels of osteogenic genes but also effectively inhibit the formation of multinucleated giant osteocasts and decrease the Rankl/Opg ratio. Overall, RIS@ZIF-8 nanoparticles could be a very promising approach to synergistically enhance osteogenic and antiresorptive properties for bone regeneration, which could be utilized for the local treatment of bone defects.
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