Journal
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
Volume 8, Issue 5, Pages 509-519Publisher
JOHN WILEY & SONS LTD
DOI: 10.1177/2050640620924157
Keywords
SARS-CoV2; COVID-19; liver injury; liver function test; cholangiocytes; lymphopenia; cytokine storm
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Patients with novel coronavirus disease 2019 (COVID-19) experience various degrees of liver function abnormalities. Liver injury requires extensive work-up and continuous surveillance and can be multifactorial and heterogeneous in nature. In the context of COVID-19, clinicians will have to determine whether liver injury is related to an underlying liver disease, drugs used for the treatment of COVID-19, direct effect of the virus, or a complicated disease course. Recent studies proposed several theories on potential mechanisms of liver injury in these patients. This review summarizes current evidence related to hepatobiliary complications in COVID-19, provides an overview of the available case series and critically elucidates the proposed mechanisms and provides recommendations for clinicians.
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