Journal
NANOMATERIALS
Volume 10, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/nano10061062
Keywords
exosomes; natural nanoparticles; SPECT imaging; biodistribution; tracking
Categories
Funding
- Ministerio de Ciencia, Innovacion y Universidades, Instituto de Salud Carlos III [PI16/02037]
- European Regional Development Fund (ERDF), A way of making Europe
- Comunidad de Madrid [Y2018/NMT-4949, S2017/BMD-3867]
- European Structural and Investment Fund
- Instituto de Salud Carlos III (ISCIII)
- Ministerio de Ciencia e Innovacion (MCIN)
- Pro CNIC Foundation
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Over the last decade, exosomes from diverse biological sources have been proposed as new natural platforms in drug delivery. Translation of these nanometric tools to clinical practice requires deep knowledge of their pharmacokinetic properties and biodistribution. The pharmacokinetic properties of exosomes are sometimes evaluated using biochemical and histological techniques that are considerably invasive. As an alternative, we present radiochemical labeling of milk-derived exosomes based on reduced(99m)Tc (IV) without modifying biological and physicochemical properties. This approach enables longitudinal tracking of natural exosomes by non-invasive single photon emission computed tomography (SPECT) imaging and the evaluation of their pharmacokinetic properties according to the route of administration.
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