Journal
CHEMSUSCHEM
Volume 9, Issue 17, Pages 2321-2325Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cssc.201600607
Keywords
amines; dehydrogenation; diols; iron catalysis; pyrrole synthesis
Funding
- EU Horizon 2020, ERC [CatASus 638076]
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Pyrroles are prominent scaffolds in pharmaceutically active compounds and play an important role in medicinal chemistry. Therefore, the development of new, atom-economic, and sustainable catalytic strategies to obtain these moieties is highly desired. Direct catalytic pathways that utilize readily available alcohol substrates have been recently established; however, these approaches rely on the use of noble metals such as ruthenium or iridium. Here, we report on the direct synthesis of pyrroles using a catalyst based on the earth-abundant and inexpensive iron. The method uses 2-butyne-1,4-diol or 2-butene-1,4-diol that can be directly coupled with anilines, benzyl amines, and aliphatic amines to obtain a variety of N-substituted pyrroles in moderate-to-excellent isolated yields.
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