Journal
CHEMSUSCHEM
Volume 10, Issue 1, Pages 58-61Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cssc.201601341
Keywords
amides; annulation; C-H activation; fluoroalkenes; rhodium
Funding
- State Key Program of National Natural Science Foundation of China [21432009]
- Nanjing Tech University
- Nanyang Technological University
- Singapore Ministry of Education Academic Research Fund [Tier 1] [MOE2015-T1-001-070 (RG5/15), MOE2014-T1-001-102 (RG9/14)]
- Singapore National Research Foundation [NRF2015NRF-POC001-024]
Ask authors/readers for more resources
A synthetic protocol for the expedient construction of 5-methylene-1H-pyrrol-2(5H)-one derivatives through rhodium-catalyzed [4+1] annulation with gem-difluoroacrylate as the C-1 component was reported. By taking advantage of the twofold C-F bond cleavage occurring during the annulation, this reaction not only allows the synthesis of these heterocyclic compounds under overall oxidant-free conditions but also renders the transformation stereospecific. The very mild reaction conditions employed ensure compatibility with a wide variety of synthetically useful functional groups.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available