Journal
CHEMSUSCHEM
Volume 10, Issue 1, Pages 119-128Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cssc.201601333
Keywords
ethyl levulinate; nitro compounds; platinum; pyrrolidones; reductive amination
Funding
- Consolider-Ingenio
- Spanish MICINN Project [CTQ-2015-67592-P]
- Generalitat Valenciana (Prometeo Program)
- Program Severo Ochoa
Ask authors/readers for more resources
N-substituted 5-methyl-2-pyrrolidones were prepared in a onepot process starting from ethyl levulinate and nitro compounds in the presence of a nanosized Pt-based catalyst. Pt supported on TiO2 nanotubes (Pt/TiO2-NT) catalyzed the synthesis of N-substituted 5-methyl-2-pyrrolidones through a cascade process involving the reduction of nitro compounds, formation of the intermediary imine, hydrogenation, and subsequent cyclization. A bifunctional metal-acid system was a suitable catalyst for the process. Pt supported on TiO2 showed lower catalytic activity than Pt/TiO2-NT owing to the strong ad-sorption of nitro compounds during the first reaction step that poisoned the acidic sites and strongly decreased the rate of amination and cyclization. However, Pt/TiO2-NT with milder acid sites was less affected by the adsorption of nitro compounds and the full cascade process could proceed. The results indicate that the prepared Pt/TiO2-NT is a chemoselective and reusable catalyst that can be applied to the synthesis of a variety of N-substituted 5-methyl-2-pyrrolidones starting from nitro compounds with excellent yields in absence of an additional organic solvent under mild reaction conditions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available