Journal
CHEMPHYSCHEM
Volume 17, Issue 16, Pages 2489-2495Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cphc.201600415
Keywords
cancer; cytotoxicity; doping; luminescence; nanoparticles
Funding
- Agency for Science, Technology and Research (A*STAR, Singapore), Joint Council Office Grant [JCOAGO3_FG03_2009]
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The structural characteristics of the seed-mediated synthesis of heterostructured CuS-ZnS nanocrystals (NCs) and Cu-doped ZnS (ZnS:Cu) NCs synthesized by two different protocols are compared and analyzed. At high Cu dopant concentrations, segregated subclusters of ZnS and CuS are observed. The photoluminescence quantum yield of ZnS:Cu NCs is about 50-80%; a value much higher than that of ZnS NCs (6%). Finally, these NCs are coated with a thin silica shell by using (3-mercaptopropyl)triethoxysilane in a reverse microemulsion to make them water soluble. Cytotoxicity experiments show that these silica-coated NCs have greatly reduced toxicity on both cancerous HeLa and noncancerous Chinese hamster ovary cells. The labeling of cancerous HeLa cells is also demonstrated.
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