Journal
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
Volume 128, Issue 4, Pages 1115-1120Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/13813455.2020.1754431
Keywords
Dexmedetomidine; ischaemia; reperfusion; ischaemic modified albumin; kidney tissue; thiol; disulphide
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This study investigated the effect of dexmedetomidine on the oxidant-antioxidant (thiol/disulphide) balance. The results showed a minimal decrease in thiol-disulphide levels in the group treated with dexmedetomidine. Additionally, dexmedetomidine was found to reduce tubular damage and necrosis in the kidneys.
Objectives: This study investigated the effect of dexmedetomidine on the oxidant-antioxidant (thiol/disulphide) balance. Methods: A total of 24 rats were divided into four groups. The renal arteries in groups IR (ischaemia/reperfusion) and IR + D (ischaemia/reperfusion + dexmedetomidine) were clamped for 45 min and reperfused for 180 min. Groups D (Dexmedetomidine) and IR + D were administered 100 mu g/kg dexmedetomidine. Oxidant-antioxidant (thiol/disulphide) levels were measured. Kidney tissue was examined histopathologically. Results: No statistically difference was found between the groups in terms of thiol-disulphide averages, while IMA, TOS and thiol-disulphide results showed a minimal decrease in Group IR + D compared to Group IR (p > 0.05). Tubular lesions and necrosis were found in 26-50% of tubules in Group IR. Tubular damage and necrosis in Group IR + D declined to 5-25% . Conclusions: No statistically difference was found in the study where OSI index, thiol/disulphide balance and IMA were measured together as biochemical values.
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