Journal
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
Volume 128, Issue 5, Pages 1242-1248Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/13813455.2020.1764048
Keywords
Acute inflammation; C-reactive protein; Band 3 protein; anion exchange; SO4= uptake
Funding
- Ministero dell'Istruzione, dell'Universita e della Ricerca (MIUR) [20152HKF3Z]
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This study found that acute inflammation affects the function of erythrocytes, leading to increased anion exchange capability of the Band 3 protein, increased lipid peroxidation, and decreased -SH groups and GSH content. Serum CRP level recovery is associated with the recovery of -SH groups and GSH, but not with the restoration of anion exchange capability. After 2 months, all parameters were completely recovered.
Objective: The impact of acute inflammation, revealed by C-reactive protein (CRP) plasma levels, has been studied on the erythrocytes anion exchanger Band 3 protein. Methods: Anion exchange capability through Band 3 protein, lipid peroxidation, -SH membrane groups and intracellular GSH levels have been measured on erythrocytes from patients with CRP >8 mg/L. Results: Under acute inflammation, a significant increase in anion exchange capability, increased lipid peroxidation, decreased-SH groups and GSH content were observed. Serum CRP levels recovery (after one week) was associated to -SH groups and GSH recovery, but not to anion exchange capability restoration. After 2 months, a total recovery of all parameters was observed. Conclusion: Band 3 protein anion exchange capability is affected by acute inflammation; the accelerated rate of anion exchange may be mainly due to lipid peroxidation, rather than to -SH groups oxidation; erythrocytes renewal could be needed to have a total recover of their function.
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