Journal
NANOSCALE RESEARCH LETTERS
Volume 15, Issue 1, Pages -Publisher
SPRINGER
DOI: 10.1186/s11671-020-03320-1
Keywords
rGO@Fe3O4 microspheres; NIR response; Magnetic target; Chemo-photothermal therapy
Funding
- National Natural Science Fund Grant [51771069]
- Tianjin Medical University Cancer Institute and Hospital Key Projects [1711]
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Near-infrared (NIR)-light responsive graphene have been shown exciting effect on cancer photothermal ablation therapy. Herein, we report on the preparation of Fe3O4-decorated hollow graphene microspheres (rGO@Fe3O4) by a facile spray drying and coprecipitation method for the magnetically targeted and NIR-responsive chemo-photothermal combination therapy. The microspheres displayed very high specific surface area (120.7 m(2) g(-1)) and large pore volume (1.012 cm(3) g(-1)), demonstrating distinct advantages for a high loading capacity of DOX (18.43%). NIR triggered photothermal effect of the rGO@Fe3O4 microspheres responded in an on-off manner and induced a high photothermal conversion efficiency. Moreover, The Fe3O4 on the microspheres exhibited an excellent tumor cells targeting ability. The chemo-photothermal treatment based on rGO@Fe3O4/DOX showed superior cytotoxicity towards Hela cells in vitro. Our studies indicated that rGO@Fe3O4/DOX microcapsules have great potential in combined chemo-photothermal cancer treatment.
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