Journal
MICROMACHINES
Volume 11, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/mi11050513
Keywords
electro-rotation; dielectrophoresis; optically-induced dielectrophoreis; alternating current (AC) electrokinetic; cell dielectric properties; microfluidic
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Funding
- National Natural Science Foundation of China [61973224, 61925307, 51805336, U1613220, U1908215, 61803323]
- Natural Science Foundation of Liaoning Province [2019-KF-01-15, 2019-ZD-0673]
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Cell dielectric properties, a type of intrinsic property of cells, can be used as electrophysiological biomarkers that offer a label-free way to characterize cell phenotypes and states, purify clinical samples, and identify target cancer cells. Here, we present a review of the determination of cell dielectric properties using alternating current (AC) electrokinetic-based microfluidic mechanisms, including electro-rotation (ROT) and dielectrophoresis (DEP). The review covers theoretically how ROT and DEP work to extract cell dielectric properties. We also dive into the details of differently structured ROT chips, followed by a discussion on the determination of cell dielectric properties and the use of these properties in bio-related applications. Additionally, the review offers a look at the future challenges facing the AC electrokinetic-based microfluidic platform in terms of acquiring cell dielectric parameters. Our conclusion is that this platform will bring biomedical and bioengineering sciences to the next level and ultimately achieve the shift from lab-oriented research to real-world applications.
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