Journal
CHEMOSPHERE
Volume 144, Issue -, Pages 510-517Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2015.09.004
Keywords
Imidacloprid; Eisenia fetida; Oxidative stress; Lipid peroxidation; DNA damage
Categories
Funding
- National Natural Science Foundation of China [21377075, 21277083, 41071164, 41001152]
- Specialized Research Fund for the Doctoral Program of Higher Education [20113702110007]
- Natural Science Foundation of Shandong [ZR2013DQ007]
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To investigate the soil ecological effect of imidacloprid, earthworm Eisenia fetida was exposed to various concentrations of imidacloprid (0.10, 0.50, and 1.00 mg kg(-1) soil) respectively after 7, 14, 21, and 28 d. The effect of imidacloprid on reactive oxygen species (ROS) generation, antioxidant enzymes activity [superoxide dismutase (SOD) and catalase (CAT), glutathione S-transferase enzyme (GST)], malondialdehyde (MDA) content and DNA damage of the E. fetida was investigated. Significant increase of the ROS level was observed. The SOD and GST activity were significantly induced at most exposure intervals. CAT activity was inhibited and reflected a dose-dependent relationship on days 7, 14 and 21. High MDA levels were observed and the olive tail moment (OTM) as well as the percentage of DNA in the comet tail (tail DNA%) in comet assay declined with increasing concentrations and exposure time after 7 d. Our results suggested that the sub-chronic exposure of imidacloprid caused DNA damage and lipid peroxidation (LPO) leading to antioxidant responses in earthworm E. fetida. (C) 2015 Elsevier Ltd. All rights reserved.
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