Journal
FRONTIERS IN MICROBIOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2020.00473
Keywords
mosquito-borne flavivirus; cis-acting RNA; RNA secondary structure; RNA-binding proteins; RNA biology
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Funding
- National Key Research and Development Program of China [2017YFD0500800]
- Sichuan-International Joint Research for Science and Technology [2018HH0098]
- China Agricultural Research System [CARS-4217]
- Program Sichuan Veterinary Medicine, Drug Innovation Group of China Agricultural Research System (CARS-SVDIP)
- Integration and Demonstration of Key Technologies for Goose Industrial Chain in Sichuan Province [2018NZ0005]
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Mosquito-borne flaviviruses (MBFVs) spread between vertebrate (mammals and birds) and invertebrate (mosquitoes) hosts. The cis-acting RNAs of MBFV share common evolutionary origins and contain frequent alterations, which control the balance of linear and circular genome conformations and allow effective replication. Importantly, multiple cis-acting RNAs interact with trans-acting regulatory RNA-binding proteins (RBPs) and affect the MBFV lifecycle process, including viral replicase binding, viral RNA translation-cyclisation-synthesis and nucleocapsid assembly. Considering that extensive structural probing analyses have been performed on MBFV cis-acting RNAs, herein the homologous RNA structures are online folded and consensus structures are constructed by sort. The specific traits and underlying biology of MBFV cis-acting RNA are illuminated accordingly in a review of RNA structure. These findings deepen our understanding of MBFV cis-acting RNA biology and serve as a resource for designing therapeutics in targeting protein-viral RNA interaction or viral RNA secondary structures.
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