Journal
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
Volume 8, Issue 20, Pages 7536-7562Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acssuschemeng.0c00125
Keywords
Bacterial cellulose; Scaffolds; Wound dressings; Tissue engineering; Drug delivery; Cancer treatment
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Funding
- Jiangsu Province Biomass Energy and Materials Laboratory in the Institute of Chemical Industry of Forest Products, CAF from Tianjin Municipal Science and Technology Bureau [JSBEM202007]
- Tianjin Enterprise Technology Commissioner project from Tianjin Municipal Science and Technology Bureau [19JCTPJC52800]
- Key Technology Research and Development Program of Tianjin from Tianjin Municipal Science and Technology Bureau [19YFZCSN00950]
- China Scholarship Council [201708120052, 201708370121]
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Bacterial cellulose (BC), with non-toxicity, high purity, and biocompatibility, has been considered as a versatile candidate for various biomedical applications. Recently, the fabrication of BC-based composite scaffolds compounded with other ingredients such as nanoparticles and polymers has received extensive investigation, which enabled the development of numerous promising biomedical products. Additionally, BC-derived nanocrystals (BCNCs) and nanofibrils (BCNFs) have proven to be promising reinforcing agents in a variety of polymeric scaffolds for biomedical applications. In this review, we summarize recent preparation strategies for BC-based and BCNCs- and BCNFs-containing composite scaffolds and their advances in biomedical applications, including wound healing, tissue engineering, and drug delivery, as well as tumor cell culture and cancer treatment. Finally, we present challenges and future perspectives for BC-based composite scaffolds for biomedical applications.
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