Journal
TOXINS
Volume 12, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/toxins12050326
Keywords
apoptosis; cancer; cell death; ion channels; scorpion toxins
Categories
Funding
- CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, Brazil)
- CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior, Brazil)
- Universidad del Cauca (Colombia)
- DPG
- DPI -FUB/UnB (Fundacao Universidade de Brasilia, Brazil)
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Apoptosis, a genetically directed process of cell death, has been studied for many years, and the biochemical mechanisms that surround it are well known and described. There are at least three pathways by which apoptosis occurs, and each pathway depends on extra or intracellular processes for activation. Apoptosis is a vital process, but disturbances in proliferation and cell death rates can lead to the development of diseases like cancer. Several compounds, isolated from scorpion venoms, exhibit inhibitory effects on different cancer cells. Indeed, some of these compounds can differentiate between healthy and cancer cells within the same tissue. During the carcinogenic process, morphological, biochemical, and biological changes occur that enable these compounds to modulate cancer but not healthy cells. This review highlights cancer cell features that enable modulation by scorpion neurotoxins. The properties of the isolated scorpion neurotoxins in cancer cells and the potential uses of these compounds as alternative treatments for cancer are discussed.
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