Journal
POLYMERS
Volume 12, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/polym12040956
Keywords
glycopolymer; stimuli-responsive; random copolymer; N-isopropylacrylamide; methacrylic acid; aggregation
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Funding
- JSPS KAKENHI [15K17870]
- Grants-in-Aid for Scientific Research [15K17870] Funding Source: KAKEN
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Stimuli-responsive polymers have attracted significant interest in the fields of advanced materials and biomaterials. Herein, temperature- and pH-responsive glycopolymers, which are composed of N-isopropylacrylamide, methacrylic acid, and an acrylamide derivative bearing a lactose moiety, were synthesized via radical copolymerization. The series of resulting glycopolymers had different degrees of substitution of the lactose moieties, were responsive to temperatures between 26.6 degrees C and 47.6 degrees C, and formed aggregates above the lower critical solution temperature limit in mild acidic aqueous media (pH 4-6). The temperature-responsive behavior was dependent on the prevailing pH conditions, as no aggregation was observed in neutral and basic aqueous media (pH > 7). The aggregates had saccharide moieties on the surface in aqueous media. The number of saccharide moieties on the surface depended on the saccharide-containing unit ratio in the glycopolymer. The ratio was determined via enzymatic hydrolysis of the lactose moieties using beta-galactosidase and the subsequent detection of the released galactose.
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