Journal
JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES
Volume 13, Issue 3, Pages -Publisher
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S1793545820500133
Keywords
Fluorescence; chemosensor; hydroperoxide; Parkinson's disease
Funding
- National Natural Science Foundation of China [61905110, 81672508]
- Jiangsu Provincial Foundation for Distinguished Young Scholars [BK20170041]
- China-Sweden Joint Mobility Project [51811530018]
- Natural Science Foundation of Shaanxi Province [2019JM-016]
- Fundamental Research Funds for the Central Universities
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Parkinson's disease (PD) is closely related to the oxidative stress induced by excess hydrogen peroxide (H2O2) in organisms. Developing an efficient method for noninvasive and real-time H2O2 detection is beneficial to investigate the role played by H2O2 in PD. In this work, a novel fluorogenic probe (CBH) for living organisms H2O2 detection has been designed, synthesized and characterized. The emission of CBH in PBS solution is very weak. However, when H2O2 was added, the fluorescence of CBH solution was sharply increased for 12-fold, accompanied by the emission peak blue-shifted from 600 to 530 nm. Moreover, the response of CBH to H2O2 is highly sensitive and selective and is not affected by various ROS/RNS, anions, cations, and amino acids. Based on the good performance of CBH for H2O2 detection, it has been successfully applied to visualizing the H2O2 concentration in living cells, Zebrafish and C. elegans PD models.
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