Lipid deposition on contact lenses in symptomatic and asymptomatic contact lens wearers

Purpose: Lipid deposition on contact lenses (CL) has traditionally been believed to reduce comfort during CL wear. The purpose of this study was to quantify lipid deposition on CL in a group of symptomatic and asymptomatic adapted CL wearers. Methods: This was a single-masked, randomized clinical trial. Only confirmed symptomatic (comfortable lens wear time (CWT) < 8 h and a noticeable reduction in comfort over the course of the day) and asymptomatic (CWT > 10 h and minimal reduction in comfort over the course of the day) participants were recruited to participate in the study. Participants wore senofilcon A lenses in combination with a polyquaternium-based care solution (OPTI-FREE Replenish). Worn CL samples were collected on Day 14. Deposited lipid amounts from the lenses (including cholesteryl ester, cholesterol and triolein) were quantified using a liquid chromatography-mass spectrometry technique. Results: Lipid deposition was significantly higher in CL extracts of asymptomatic wearers compared to the symptomatic wearers for all lipid types quantified, including cholesteryl ester (2.1 +/- 0.6 vs 1.6 +/- 0.5 log mu g/lens), cholesterol (1.5 +/- 0.3 vs 1.1 +/- 0.3 log mu g/lens) and triolein (0.3 +/- 0.2 vs 0.1 +/- 0.1 log mu g/lens) (all p < 0.002). The amount of cholesteryl ester deposited was greatest (p = 0.0001), followed by cholesterol, then triolein, for both the asymptomatic and symptomatic groups (both p = 0.0001). Conclusion: This study demonstrated that the asymptomatic group deposited a significantly greater amount of lipid on their CL. Although lipid levels measured are considered low to trigger any observable clinical deposition, they may influence other clinical outcomes, particularly comfort.

Automated summary

Lipid deposition was significantly higher in the asymptomatic group compared to symptomatic wearers. Cholesteryl ester deposition was found to be the highest among all lipid types. Although the measured lipid levels are considered low for clinical deposition, they may impact other clinical outcomes such as comfort.